Hudspeth County is situated on the Diablo Plateau of the Trans-Pecos, where there are two square miles of fresh air scenic space for each inhabitant .Bordered by El Paso County on the west, Culberson County on the east. New Mexico on the north, and Old Mexico on the south.

There are five major mountain regions including the Huecos, Sierra Diablo, Eagles, Finlays, and Quitmans. There are plains of gramma grass and rich fertile valleys. The elevation of the county varies from 3,200 feet in the Rio Grand Valley to 5,000 feet in the central plateau, to peaks in the mountains of over 7,000 feet.